| Titel |
Eisenregulation unter physiologischen und pathologischen Bedingungen
|
| Title |
Iron Regulation in Health and Disease |
| Schwerpunkt/Focus |
|
| Sprache/Language |
optional |
| VV-Nr./Course No. |
134356 |
| Modulverantwortlich/Responsible |
Dr. Lisa Schrader |
| Vertreter/Co-responsible |
|
| Anbieter/Teachers |
Dr. Lisa Schrader |
| Typ/Type |
Seminar, Praktikum |
| SWS/Semerster periods per week |
|
| Arbeitslast(h)/Work load |
150h |
| KP/Credit points |
5 KP |
| Zuordnung/Classification |
Fortgeschrittenen-Modul |
| Semester/Semester |
SoSe
WiSe |
| Studierende/Students |
MSc Biowissenschaften
MSc Biotechnologie
MSc Molekulare Biomedizin |
| Corona-Informationen/Corona-Information |
|
| Zeit/Date |
Block I, 27.04.26 - 22.05.26 |
| Ort/Location |
UKM, Domagkstr. 3 |
| Beginn/Start |
9Uhr |
| Vorbesprechung/Obligatory pre-meeting |
Upon agreement, prior to the start of the module |
| Voraussetzung/Prerequisite |
keine |
| Anmeldung/Registration |
Online-Anmeldung |
| Leistungskontrollen/Performance assessments |
Vortrag und Protokoll |
| Termine f. Leistungskontrollen/Date for performance assessments |
|
| max. NP/Max. grade points |
200 NP |
| Ziele/Aims |
The aim of this module is to convey a clear understanding of the fundamental principles of iron regulation, highlighting how the body maintains iron balances and why this process is essential for health. By the end of the module, students will be prepared to grasp the clinical and practical aspects of iron-related disorders. |
| Inhalte/Content |
Iron is an essential element for all living organisms, because iron is involved in critical cellular and biological processes, including oxygen transport and energy metabolism. Although required for normal cellular functions, iron is also potentially toxic: it participates in the Fenton reaction, which results in the production of reactive oxygen species (ROS). ROS may cause damage to many cellular components, including DNA, lipids and proteins and may induce cell death. Humans and other organisms therefore evolved specialized proteins and tightly regulated homeostatic mechanisms for the uptake, transport, storage, and export of iron to provide adequate iron for essential biologic process, but to limit the toxicity of iron excess. This module explores the mechanisms that control iron absorption, transport, storage and utilization, as well as the consequences of its dysregulation. Emphasis is placed on linking these basic concepts to their relevance in health and disease. |
| Methoden/Methods |
During the module, students will gain hands-on experience working with both adherent and suspension cell cultures. Following stimulation with specific ligands, the cells will be analyzed for their iron profile using a range of molecular and cellular techniques, including quantitative PCR (qPCR), Western blotting, and immunofluorescence. Students will also become familiar with various colorimetric assays used to assess iron status and levels in vivo.Additionally, students will be introduced to non-viral gene transfer methods to modulate the expression of proteins involved in iron regulation |
| Berufsrelevante und interdisziplinäre Komponenten/Occupational and interdisciplinary skills |
|
| Voraussetzung für/Prerequisite for |
|
| Präsenzpflicht/Compulsory presence |
ja |
| Plätze/Number of participants |
2 |
| Gruppengröße/Group size |
|
| Materialien/Materials |
|
| Literatur/Literature |
Literature will be provided during the module. |
| Links |
|
| Sonstiges/Further information |
|
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= Modul gehört zum SPP Neuroscience and Behaviour /Module is part of the SSP Neuroscience and Behaviour
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