Veranstaltung
| Titel | Kollektive Zellmigration und "Looping"-Morphogenese in Drosophila |
| Title | Collective Cell Migration and Looping Morphogenesis in Drosophila |
| Schwerpunkt/Focus | |
| Sprache/Language | optional |
| VV-Nr./Course No. | 134360 |
| Modulverantwortlich/Responsible | Dr. Maik Bischoff |
| Vertreter/Co-responsible | |
| Anbieter/Teachers | Dr. Maik Bischoff |
| Typ/Type | Praktikum |
| SWS/Semerster periods per week | |
| Arbeitslast(h)/Work load | 300 h |
| KP/Credit points | 10 kp |
| Zuordnung/Classification | Forschungs-Modul |
| Semester/Semester | SoSe WiSe |
| Studierende/Students | MSc Biowissenschaften MSc Biotechnologie MSc Molekulare Biomedizin |
| Corona-Informationen/Corona-Information | |
| Zeit/Date | 8 Wochen |
| Ort/Location | Multiscale Imaging Centre (MIC) Room 209 |
| Beginn/Start | n. A. |
| Vorbesprechung/Obligatory pre-meeting | n. A. |
| Voraussetzung/Prerequisite | 'keine' |
| Anmeldung/Registration | |
| Leistungskontrollen/Performance assessments | Protokoll |
| Termine f. Leistungskontrollen/Date for performance assessments | |
| max. NP/Max. grade points | 200 NP |
| Ziele/Aims | The students will acquire hands-on experience in molecular biology, developmental cell biology, and genetic approaches in Drosophila, as well as in documenting experimental results using microscopy. |
| Inhalte/Content | We are interested in how looped organs such as the gut and heart are remodeled during development and how they acquire chirality. Using the fruit fly (Drosophila) testis as a model, we investigate how a motile layer of muscle precursors deforms the gonad, combining a wide range of experimental approaches. |
| Methoden/Methods | We combine live imaging (Spinning Disc Microscopy), quantitative image analysis, genetic manipulation (e.g. RNAi, Mutants, conditional overexpression) and immunohistochemistry. |
| Berufsrelevante und interdisziplinäre Komponenten/Occupational and interdisciplinary skills | |
| Voraussetzung für/Prerequisite for | |
| Präsenzpflicht/Compulsory presence | ja/yes |
| Plätze/Number of participants | 1 |
| Gruppengröße/Group size | optional |
| Materialien/Materials | |
| Literatur/Literature | Bischoff, M. C., R. Mayor. 2025. Patterning in motion: Cell interfaces guide mesenchymal collective migration and morphogenesis. Journal of Cell Biology, 224(11), e202505198. DOI: 10.1083/jcb.202505198 Bischoff, M. C., J. E. Norton, S. E. Clark, M. Peifer. 2025. Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance. Science Advances, 11(25), eadu3741. DOI: 10.1126/sciadv.adu3741 |
| Links | https://www.bischofflab.com/ |
| Sonstiges/Further information |
Modulelemente:
Elemente of the module:
| Titel/Title | Zeit (von...bis)/Time (from...to) | Ort(Raum)/Location | |
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| Übungen/Practical exercises | |||
| Vorlesung/Lecture | |||
| Seminare/Semeinars | |||
| Exkursionen/Excursions |
= Modul gehört zum SPP Imoplant / Module is part of the SSP Imoplant
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= Modul gehört zum SPP Neuroscience and Behaviour /Module is part of the SSP Neuroscience and Behaviour
= Modul gehört zum SPP Quantitative Cell Biology /Module is part of the SSP Quantitative Cell Biology